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7lhv
From Proteopedia
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==Structure of Arabidopsis thaliana sulfate transporter AtSULTR4;1== | ==Structure of Arabidopsis thaliana sulfate transporter AtSULTR4;1== | ||
| - | <StructureSection load='7lhv' size='340' side='right'caption='[[7lhv]]' scene=''> | + | <StructureSection load='7lhv' size='340' side='right'caption='[[7lhv]], [[Resolution|resolution]] 2.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LHV FirstGlance]. <br> | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LHV FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lhv OCA], [https://pdbe.org/7lhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lhv RCSB], [https://www.ebi.ac.uk/pdbsum/7lhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lhv ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.75Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LBN:1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine'>LBN</scene>, <scene name='pdbligand=S1P:(2S,3R,4E)-2-AMINO-3-HYDROXYOCTADEC-4-EN-1-YL+DIHYDROGEN+PHOSPHATE'>S1P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lhv OCA], [https://pdbe.org/7lhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lhv RCSB], [https://www.ebi.ac.uk/pdbsum/7lhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lhv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Plant sulfate transporters (SULTR) mediate absorption and distribution of sulfate (SO4(2-)) and are essential for plant growth; however, our understanding of their structures and functions remains inadequate. Here we present the structure of a SULTR from Arabidopsis thaliana, AtSULTR4;1, in complex with SO4(2-) at an overall resolution of 2.8 A. AtSULTR4;1 forms a homodimer and has a structural fold typical of the SLC26 family of anion transporters. The bound SO4(2-) is coordinated by side-chain hydroxyls and backbone amides, and further stabilized electrostatically by the conserved Arg393 and two helix dipoles. Proton and SO4(2-) are co-transported by AtSULTR4;1 and a proton gradient significantly enhances SO4(2-) transport. Glu347, which is ~7 A from the bound SO4(2-), is required for H(+)-driven transport. The cytosolic STAS domain interacts with transmembrane domains, and deletion of the STAS domain or mutations to the interface compromises dimer formation and reduces SO4(2-) transport, suggesting a regulatory function of the STAS domain. | ||
| + | |||
| + | Structure and function of an Arabidopsis thaliana sulfate transporter.,Wang L, Chen K, Zhou M Nat Commun. 2021 Jul 22;12(1):4455. doi: 10.1038/s41467-021-24778-2. PMID:34294705<ref>PMID:34294705</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7lhv" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Structure of Arabidopsis thaliana sulfate transporter AtSULTR4;1
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Categories: Large Structures | Chen K | Wang L | Zhou M
