7moq
From Proteopedia
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| - | ==== | + | ==The structure of the Tetrahymena thermophila outer dynein arm on doublet microtubule== |
| - | <StructureSection load='7moq' size='340' side='right'caption='[[7moq]]' scene=''> | + | <StructureSection load='7moq' size='340' side='right'caption='[[7moq]], [[Resolution|resolution]] 8.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7moq]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila_CU428 Tetrahymena thermophila CU428]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MOQ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7moq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7moq OCA], [https://pdbe.org/7moq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7moq RCSB], [https://www.ebi.ac.uk/pdbsum/7moq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7moq ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7moq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7moq OCA], [https://pdbe.org/7moq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7moq RCSB], [https://www.ebi.ac.uk/pdbsum/7moq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7moq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q22A67_TETTS Q22A67_TETTS] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cilia are thin microtubule-based protrusions of eukaryotic cells. The swimming of ciliated protists and sperm cells is propelled by the beating of cilia. Cilia propagate the flow of mucus in the trachea and protect the human body from viral infections. The main force generators of ciliary beating are the outer dynein arms (ODAs) which attach to the doublet microtubules. The bending of cilia is driven by the ODAs' conformational changes caused by ATP hydrolysis. Here, we report the native ODA complex structure attaching to the doublet microtubule by cryo-electron microscopy. The structure reveals how the ODA complex is attached to the doublet microtubule via the docking complex in its native state. Combined with coarse-grained molecular dynamic simulations, we present a model of how the attachment of the ODA to the doublet microtubule induces remodeling and activation of the ODA complex. | ||
| + | |||
| + | Remodeling and activation mechanisms of outer arm dyneins revealed by cryo-EM.,Kubo S, Yang SK, Black CS, Dai D, Valente-Paterno M, Gaertig J, Ichikawa M, Bui KH EMBO Rep. 2021 Sep 6;22(9):e52911. doi: 10.15252/embr.202152911. Epub 2021 Aug 2. PMID:34338432<ref>PMID:34338432</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7moq" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dynein 3D structures|Dynein 3D structures]] | ||
| + | *[[Thioredoxin 3D structures|Thioredoxin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Tetrahymena thermophila CU428]] |
| + | [[Category: Bui KH]] | ||
| + | [[Category: Ichikawa M]] | ||
| + | [[Category: Kubo S]] | ||
| + | [[Category: Yang SK]] | ||
Current revision
The structure of the Tetrahymena thermophila outer dynein arm on doublet microtubule
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