7w0g

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Current revision (19:43, 29 May 2024) (edit) (undo)
 
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<StructureSection load='7w0g' size='340' side='right'caption='[[7w0g]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
<StructureSection load='7w0g' size='340' side='right'caption='[[7w0g]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7w0g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W0G FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W0G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=85B:2-[2,6-dimethyl-4-[[5-oxidanylidene-4-[4-(trifluoromethyloxy)phenyl]-1,2,4-triazol-1-yl]methyl]phenoxy]-2-methyl-propanoic+acid'>85B</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.443&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=85B:2-[2,6-dimethyl-4-[[5-oxidanylidene-4-[4-(trifluoromethyloxy)phenyl]-1,2,4-triazol-1-yl]methyl]phenoxy]-2-methyl-propanoic+acid'>85B</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w0g OCA], [https://pdbe.org/7w0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w0g RCSB], [https://www.ebi.ac.uk/pdbsum/7w0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w0g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w0g OCA], [https://pdbe.org/7w0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w0g RCSB], [https://www.ebi.ac.uk/pdbsum/7w0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w0g ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7w0g" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7w0g" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dai, L]]
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[[Category: Dai L]]
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[[Category: Feng, Z Q]]
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[[Category: Feng ZQ]]
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[[Category: Sun, H B]]
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[[Category: Sun HB]]
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[[Category: Yuan, H L]]
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[[Category: Yuan HL]]
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[[Category: Agonist]]
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[[Category: Complex]]
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[[Category: Nuclear protein]]
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[[Category: Peroxisome proliferator-activated receptor]]
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Current revision

Human PPAR delta ligand binding domain in complex with a synthetic agonist H11

PDB ID 7w0g

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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