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7wn7
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7wn7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicoverpa_armigera_nucleopolyhedrovirus_G4 Helicoverpa armigera nucleopolyhedrovirus G4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WN7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7wn7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicoverpa_armigera_nucleopolyhedrovirus_G4 Helicoverpa armigera nucleopolyhedrovirus G4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WN7 FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wn7 OCA], [https://pdbe.org/7wn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wn7 RCSB], [https://www.ebi.ac.uk/pdbsum/7wn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wn7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wn7 OCA], [https://pdbe.org/7wn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wn7 RCSB], [https://www.ebi.ac.uk/pdbsum/7wn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wn7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/Q99H25_9ABAC Q99H25_9ABAC] Nuclease that cleaves host 2',3'-cGAMP.[HAMAP-Rule:MF_04143] | [https://www.uniprot.org/uniprot/Q99H25_9ABAC Q99H25_9ABAC] Nuclease that cleaves host 2',3'-cGAMP.[HAMAP-Rule:MF_04143] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | P26, a homolog of the viral-encoded nuclease poxin that neutralizes the cGAS-STING innate immunity, is widely distributed in various invertebrate viruses, lepidopteran insects, and parasitoid wasps. P26/poxin from certain insect viruses also retains protease activity, though its biological role remains unknown. Given that many P26s contain a signal peptide, it is surmised that P26 may possess certain extracellular functions. Here, we report that a secretory baculoviral P26 suppresses melanization, a prominent insect innate immunity against pathogen invasion. P26 targets the cofactor of a prophenoloxidase-activating protease, and its inhibitory function is independent of nuclease activity. The analysis of P26/poxin homologs from different origins suggests that the ability to inhibit the extracellular melanization pathway is limited to P26s with a signal peptide and not shared by the homologs without it. These findings highlight the independent evolution of a single viral suppressor to perform dual roles in modulating immunity during virus-host adaptation. | ||
| + | |||
| + | Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity.,Yin M, Kuang W, Wang Q, Wang X, Yuan C, Lin Z, Zhang H, Deng F, Jiang H, Gong P, Zou Z, Hu Z, Wang M Nat Commun. 2022 Nov 14;13(1):6934. doi: 10.1038/s41467-022-34761-0. PMID:36376305<ref>PMID:36376305</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7wn7" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of HearNPV P26
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