7y77
From Proteopedia
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NARROW LEAF 1 (NAL1) is a breeding-valuable pleiotropic gene that affects multiple agronomic traits in rice, although the molecular mechanism is largely unclear. Here, we report that NAL1 is a serine protease and displays a novel hexameric structure consisting of two ATP-mediated doughnut-shaped trimeric complexes. Moreover, we identified TOPLESS-related corepressor OsTPR2 involved in multiple growth and development processes as the substrate of NAL1. We found that NAL1 degraded OsTPR2, thus modulating the expression of downstream genes related to hormone signalling pathways, eventually achieving its pleiotropic physiological function. An elite allele, NAL1(A), which may have originated from wild rice, could increase grain yield. Furthermore, the NAL1 homologues in different crops have a similar pleiotropic function to NAL1. Our study uncovers a NAL1-OsTPR2 regulatory module and provides gene resources for the design of high-yield crops. | NARROW LEAF 1 (NAL1) is a breeding-valuable pleiotropic gene that affects multiple agronomic traits in rice, although the molecular mechanism is largely unclear. Here, we report that NAL1 is a serine protease and displays a novel hexameric structure consisting of two ATP-mediated doughnut-shaped trimeric complexes. Moreover, we identified TOPLESS-related corepressor OsTPR2 involved in multiple growth and development processes as the substrate of NAL1. We found that NAL1 degraded OsTPR2, thus modulating the expression of downstream genes related to hormone signalling pathways, eventually achieving its pleiotropic physiological function. An elite allele, NAL1(A), which may have originated from wild rice, could increase grain yield. Furthermore, the NAL1 homologues in different crops have a similar pleiotropic function to NAL1. Our study uncovers a NAL1-OsTPR2 regulatory module and provides gene resources for the design of high-yield crops. | ||
| - | Serine protease NAL1 exerts pleiotropic functions through degradation of TOPLESS-related corepressor in rice.,Li W, Yan J, Zhang Y, Zhang F, Guan Z, Yao Y, Chang Y, Tu H, Li X, Wang H, Xiong H, Lai X, Yin P, Xiong L Nat Plants. 2023 | + | Serine protease NAL1 exerts pleiotropic functions through degradation of TOPLESS-related corepressor in rice.,Li W, Yan J, Zhang Y, Zhang F, Guan Z, Yao Y, Chang Y, Tu H, Li X, Wang H, Xiong H, Lai X, Yin P, Xiong L Nat Plants. 2023 Jul;9(7):1130-1142. doi: 10.1038/s41477-023-01449-2. Epub 2023 , Jun 22. PMID:37349549<ref>PMID:37349549</ref> |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
Current revision
Crystal structure of rice NAL1
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Categories: Large Structures | Oryza sativa | Guan ZY | Xiong LZ | Yan JJ | Yin P
