8rc0
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rc0 OCA], [https://pdbe.org/8rc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rc0 RCSB], [https://www.ebi.ac.uk/pdbsum/8rc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rc0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rc0 OCA], [https://pdbe.org/8rc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rc0 RCSB], [https://www.ebi.ac.uk/pdbsum/8rc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rc0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/PRP6_HUMAN PRP6_HUMAN] Retinitis pigmentosa. The disease may be caused by mutations affecting the gene represented in this entry. Cells from RP60 patients show intron retention for pre-mRNA bearing specific splicing signals. | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ | + | [https://www.uniprot.org/uniprot/CD2B2_HUMAN CD2B2_HUMAN] |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The 20S U5 small nuclear ribonucleoprotein particle (snRNP) is a 17-subunit RNA-protein complex and a precursor of the U4/U6.U5 tri-snRNP, the major building block of the precatalytic spliceosome. CD2BP2 is a hallmark protein of the 20S U5 snRNP, absent from the mature tri-snRNP. Here we report a high-resolution cryogenic electron microscopy structure of the 20S U5 snRNP, shedding light on the mutually exclusive interfaces utilized during tri-snRNP assembly and the role of the CD2BP2 in facilitating this process. | ||
| + | |||
| + | Structure of the human 20S U5 snRNP.,Schneider S, Brandina I, Peter D, Lagad S, Fraudeau A, Portell-Montserrat J, Tholen J, Zhao J, Galej WP Nat Struct Mol Biol. 2024 May;31(5):752-756. doi: 10.1038/s41594-024-01250-5. , Epub 2024 Mar 11. PMID:38467877<ref>PMID:38467877</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 8rc0" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Structure of the human 20S U5 snRNP
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