1skn

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[[Image:1skn.gif|left|200px]]
[[Image:1skn.gif|left|200px]]
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{{Structure
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|PDB= 1skn |SIZE=350|CAPTION= <scene name='initialview01'>1skn</scene>, resolution 2.500&Aring;
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The line below this paragraph, containing "STRUCTURE_1skn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= SKN-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])
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|DOMAIN=
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{{STRUCTURE_1skn| PDB=1skn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1skn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skn OCA], [http://www.ebi.ac.uk/pdbsum/1skn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1skn RCSB]</span>
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'''THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF'''
'''THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF'''
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[[Category: Matthews, B W.]]
[[Category: Matthews, B W.]]
[[Category: Rupert, P B.]]
[[Category: Rupert, P B.]]
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[[Category: complex (transcription factor/dna)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:49:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:43:18 2008''
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Revision as of 05:49, 3 May 2008

Image:1skn.gif

Template:STRUCTURE 1skn

THE BINDING DOMAIN OF SKN-1 IN COMPLEX WITH DNA: A NEW DNA-BINDING MOTIF


Overview

The DNA-binding domain of Skn-1, a developmental transcription factor that specifies mesoderm in C. elegans, is shown by X-ray crystallography to have a novel fold in which a compact, monomeric, four-helix unit organizes two DNA-contact elements. At the C-terminus, a helix extends from the domain to occupy the major groove of DNA in a manner similar to bZip proteins. Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'.

About this Structure

1SKN is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

A new DNA-binding motif in the Skn-1 binding domain-DNA complex., Rupert PB, Daughdrill GW, Bowerman B, Matthews BW, Nat Struct Biol. 1998 Jun;5(6):484-91. PMID:9628487 Page seeded by OCA on Sat May 3 08:49:09 2008

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