1w50

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[[Category: zymogen]]
[[Category: zymogen]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 17:25:48 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:46:46 2007''

Revision as of 17:40, 12 November 2007

Image:1w50.gif

1w50, resolution 1.75Å

Drag the structure with the mouse to rotate

APO STRUCTURE OF BACE (BETA SECRETASE)

Overview

Human BACE, also known as beta-secretase, shows promise as a potential, therapeutic target for Alzheimer's disease. We determined the apo, structure of BACE to 1.75 A, and a structure of a hydroxyethylamine, inhibitor complex derived by soaking. These show significant active-site, movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by, structure-based drug design.

About this Structure

1W50 is a Single protein structure of sequence from Homo sapiens with IOD as ligand. Active as Memapsin 2, with EC number 3.4.23.46 Structure known Active Site: AC2. Full crystallographic information is available from OCA.

Reference

Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669

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