8bpq

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Current revision (05:15, 5 June 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8bpq is ON HOLD until Paper Publication
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==crystal structure of N-ethylmaleimide reductase with mutation Y187F (nemA Y187F) from Escherichia coli==
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<StructureSection load='8bpq' size='340' side='right'caption='[[8bpq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8bpq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPQ FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7MT:Tb-Xo4'>7MT</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpq OCA], [https://pdbe.org/8bpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpq RCSB], [https://www.ebi.ac.uk/pdbsum/8bpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEMA_ECOLI NEMA_ECOLI] Involved in the degradation of toxic compounds (PubMed:15184158, PubMed:17504490, PubMed:23506073, PubMed:23527133, PubMed:23536188, PubMed:9013822). Can use a variety of substrates, including the nitrate ester explosives glycerol trinitrate (GTN) and pentaerythritol tetranitrate (PETN), chromate and various electrophiles such as quinones (PubMed:15184158, PubMed:23506073, PubMed:23527133). Involved in resistance to hypochlorous acid (HOCl), which is the active component of household bleach and a powerful antimicrobial during the innate immune response (PubMed:23536188). Catalyzes the reduction of N-ethylmaleimide (NEM) to N-ethylsuccinimide (PubMed:23506073, PubMed:9013822). Together with NfsA and NfsB, can use the nitroaromatic explosive 2,4,6-trinitrotoluene (TNT) (PubMed:17504490).<ref>PMID:15184158</ref> <ref>PMID:17504490</ref> <ref>PMID:23506073</ref> <ref>PMID:23527133</ref> <ref>PMID:23536188</ref> <ref>PMID:9013822</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Erb T]]
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[[Category: Pfister P]]
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[[Category: Tinzl M]]

Current revision

crystal structure of N-ethylmaleimide reductase with mutation Y187F (nemA Y187F) from Escherichia coli

PDB ID 8bpq

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