8fpx

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Current revision (05:15, 5 June 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8fpx is ON HOLD until Paper Publication
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==Crystal structure of tumor related RhoA mutant A161P in complex with GDP==
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<StructureSection load='8fpx' size='340' side='right'caption='[[8fpx]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
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Authors: Lin, Y., Zheng, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8fpx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FPX FirstGlance]. <br>
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Description: Crystal structure of tumor related RhoA mutant A161P in complex with GDP
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Zheng, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fpx OCA], [https://pdbe.org/8fpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fpx RCSB], [https://www.ebi.ac.uk/pdbsum/8fpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fpx ProSAT]</span></td></tr>
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[[Category: Lin, Y]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Lin Y]]
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[[Category: Zheng Y]]

Current revision

Crystal structure of tumor related RhoA mutant A161P in complex with GDP

PDB ID 8fpx

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