8p2p
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Polymeric form of the BTB domain of human ZBTB18== | |
| - | + | <StructureSection load='8p2p' size='340' side='right'caption='[[8p2p]], [[Resolution|resolution]] 4.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8p2p]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P2P FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.15Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p2p OCA], [https://pdbe.org/8p2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p2p RCSB], [https://www.ebi.ac.uk/pdbsum/8p2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p2p ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Coste | + | == Disease == |
| - | [[Category: Mance | + | [https://www.uniprot.org/uniprot/ZBT18_HUMAN ZBT18_HUMAN] Distal deletion 1q. The disease is caused by variants affecting the gene represented in this entry. |
| - | [[Category: Pukalo | + | == Function == |
| + | [https://www.uniprot.org/uniprot/ZBT18_HUMAN ZBT18_HUMAN] Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.<ref>PMID:9756912</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Coste F]] | ||
| + | [[Category: Mance L]] | ||
| + | [[Category: Pukalo Z]] | ||
| + | [[Category: Suskiewicz MJ]] | ||
Current revision
Polymeric form of the BTB domain of human ZBTB18
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