8p5l

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Current revision (05:17, 5 June 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8p5l is ON HOLD until Paper Publication
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==Kinase domain of mutant human ULK1 in complex with compound MRT67307==
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<StructureSection load='8p5l' size='340' side='right'caption='[[8p5l]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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Authors: Battista, T., Semrau, M.S., Heroux, A., Lolli, G., Storici, P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8p5l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P5L FirstGlance]. <br>
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Description: Kinase domain of mutant human ULK1 in complex with compound MRT67307
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.836&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FV:N-{3-[(5-CYCLOPROPYL-2-{[3-(MORPHOLIN-4-YLMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PROPYL}CYCLOBUTANECARBOXAMIDE'>1FV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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[[Category: Heroux, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p5l OCA], [https://pdbe.org/8p5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p5l RCSB], [https://www.ebi.ac.uk/pdbsum/8p5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p5l ProSAT]</span></td></tr>
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[[Category: Lolli, G]]
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</table>
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[[Category: Storici, P]]
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== Function ==
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[[Category: Semrau, M.S]]
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[https://www.uniprot.org/uniprot/ULK1_HUMAN ULK1_HUMAN] Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.<ref>PMID:18936157</ref> <ref>PMID:21460634</ref> <ref>PMID:21795849</ref>
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[[Category: Battista, T]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Battista T]]
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[[Category: Heroux A]]
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[[Category: Lolli G]]
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[[Category: Semrau MS]]
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[[Category: Storici P]]

Current revision

Kinase domain of mutant human ULK1 in complex with compound MRT67307

PDB ID 8p5l

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