7e4i
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Cryo-EM structure of the yeast mitochondrial SAM-Tom40/Tom5/Tom6 complex at 3.0 angstrom== |
| - | <StructureSection load='7e4i' size='340' side='right'caption='[[7e4i]]' scene=''> | + | <StructureSection load='7e4i' size='340' side='right'caption='[[7e4i]], [[Resolution|resolution]] 3.05Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7e4i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E4I FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e4i OCA], [https://pdbe.org/7e4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e4i RCSB], [https://www.ebi.ac.uk/pdbsum/7e4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e4i ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.05Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e4i OCA], [https://pdbe.org/7e4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e4i RCSB], [https://www.ebi.ac.uk/pdbsum/7e4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e4i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SAM50_YEAST SAM50_YEAST] Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex.<ref>PMID:14570913</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | beta barrel outer membrane proteins (beta-OMPs) play vital roles in mitochondria, chloroplasts, and Gram-negative bacteria. Evolutionarily conserved complexes such as the mitochondrial sorting and assembly machinery (SAM) mediate the assembly of beta-OMPs. We investigated the SAM-mediated assembly of the translocase of the outer membrane (TOM) core complex. Cryo-electron microscopy structures of SAM-fully folded Tom40 and the SAM-Tom40/Tom5/Tom6 complexes at ~3-angstrom resolution reveal that Sam37 stabilizes the mature Tom40 mainly through electrostatic interactions, thus facilitating subsequent TOM assembly. These results support the beta barrel switching model and provide structural insights into the assembly and release of beta barrel complexes. | ||
| + | |||
| + | Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex.,Wang Q, Guan Z, Qi L, Zhuang J, Wang C, Hong S, Yan L, Wu Y, Cao X, Cao J, Yan J, Zou T, Liu Z, Zhang D, Yan C, Yin P Science. 2021 Sep 17;373(6561):1377-1381. doi: 10.1126/science.abh0704. Epub 2021 , Aug 26. PMID:34446444<ref>PMID:34446444</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7e4i" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Saccharomyces cerevisiae S288C]] |
| + | [[Category: Guan ZY]] | ||
| + | [[Category: Qi LB]] | ||
| + | [[Category: Wang Q]] | ||
| + | [[Category: Yan CY]] | ||
| + | [[Category: Yin P]] | ||
Current revision
Cryo-EM structure of the yeast mitochondrial SAM-Tom40/Tom5/Tom6 complex at 3.0 angstrom
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