7etm

<table><tr><td colspan='2'>[[7etm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_cytomegalovirus Human cytomegalovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ETM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ETM FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7etm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7etm OCA], [https://pdbe.org/7etm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7etm RCSB], [https://www.ebi.ac.uk/pdbsum/7etm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7etm ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/Q6RXD3_HCMV Q6RXD3_HCMV]] Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocates the viral DNA, termed terminase.[HAMAP-Rule:MF_04012]

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

How the human cytomegalovirus (HCMV) genome-the largest among human herpesviruses-is packaged, retained, and ejected remains unclear. We present the in situ structures of the symmetry-mismatched portal and the capsid vertex-specific components (CVSCs) of HCMV. The 5-fold symmetric 10-helix anchor-uncommon among known portals-contacts the portal-encircling DNA, which is presumed to squeeze the portal as the genome packaging proceeds. We surmise that the 10-helix anchor dampens this action to delay the portal reaching a "head-full" packaging state, thus facilitating the large genome to be packaged. The 6-fold symmetric turret, latched via a coiled coil to a helix from a major capsid protein, supports the portal to retain the packaged genome. CVSCs at the penton vertices-presumed to increase inner capsid pressure-display a low stoichiometry, which would aid genome retention. We also demonstrate that the portal and capsid undergo conformational changes to facilitate genome ejection after viral cell entry.

 

== References ==

[[Category: Human cytomegalovirus]]

[[Category: Li, Z]]

[[Category: Yu, X]]

[[Category: Viral protein]]