7n97

==State 2 of TcdB and FZD2 at pH5==

<StructureSection load='7n97' size='340' side='right'caption='[[7n97]], [[Resolution|resolution]] 5.10&Aring;' scene=''>

<table><tr><td colspan='2'>[[7n97]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N97 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.1&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n97 OCA], [https://pdbe.org/7n97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n97 RCSB], [https://www.ebi.ac.uk/pdbsum/7n97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n97 ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/FZD2_HUMAN FZD2_HUMAN] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

[[Category: Clostridioides difficile]]

[[Category: Homo sapiens]]

[[Category: Jiang M]]

[[Category: Zhang J]]