1smo

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[[Image:1smo.gif|left|200px]]
[[Image:1smo.gif|left|200px]]
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{{Structure
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|PDB= 1smo |SIZE=350|CAPTION= <scene name='initialview01'>1smo</scene>, resolution 1.47&Aring;
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The line below this paragraph, containing "STRUCTURE_1smo", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= trem-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1smo| PDB=1smo | SCENE= }}
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|RELATEDENTRY=[[1q8m|1Q8M]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1smo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smo OCA], [http://www.ebi.ac.uk/pdbsum/1smo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1smo RCSB]</span>
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}}
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'''Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .'''
'''Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .'''
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[[Category: Teyton, L.]]
[[Category: Teyton, L.]]
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
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[[Category: activating receptor]]
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[[Category: Activating receptor]]
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[[Category: innate immune system receptor]]
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[[Category: Innate immune system receptor]]
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[[Category: structure]]
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[[Category: Structure]]
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[[Category: trem-1]]
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[[Category: Trem-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:53:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:44:13 2008''
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Revision as of 05:53, 3 May 2008

Image:1smo.gif

Template:STRUCTURE 1smo

Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .


Overview

The triggering receptor expressed on myeloid cells (TREM) family of single extracellular immunoglobulin receptors includes both activating and inhibitory isoforms whose ligands are unknown. TREM-1 activation amplifies the Toll-like receptor initiated responses to invading pathogens allowing the secretion of pro-inflammatory chemokines and cytokines. Hence, TREM-1 amplifies the inflammation induced by both bacteria and fungi, and thus represents a potential therapeutic target. We report the crystal structure of the human TREM-1 extracellular domain at 1.47 A resolution. The overall fold places it within the V-type immunoglobulin domain family and reveals close homology with Ig domains from antibodies, T-cell receptors and other activating receptors, such as NKp44. With the additional use of analytical ultracentrifugation and 1H NMR spectroscopy of both human and mouse TREM-1, we have conclusively demonstrated the monomeric state of this extracellular ectodomain in solution and, presumably, of the TREM family in general.

About this Structure

1SMO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A., Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wuthrich K, Wilson IA, J Mol Biol. 2004 Sep 24;342(4):1237-48. PMID:15351648 Page seeded by OCA on Sat May 3 08:53:42 2008

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