7rwz
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==SaPIbov5 procapsid structure including size redirecting protein Ccm== |
| - | <StructureSection load='7rwz' size='340' side='right'caption='[[7rwz]]' scene=''> | + | <StructureSection load='7rwz' size='340' side='right'caption='[[7rwz]], [[Resolution|resolution]] 4.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rwz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RWZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rwz OCA], [https://pdbe.org/7rwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rwz RCSB], [https://www.ebi.ac.uk/pdbsum/7rwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rwz ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rwz OCA], [https://pdbe.org/7rwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rwz RCSB], [https://www.ebi.ac.uk/pdbsum/7rwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rwz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/E2FZQ5_STAAU E2FZQ5_STAAU] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Staphylococcus aureus pathogenicity islands (SaPIs) are molecular parasites that hijack helper phages for their transfer. SaPIbov5, the prototypical member of a family of cos type SaPIs, redirects the assembly of varphi12 helper capsids from prolate to isometric. This size and shape shift is dependent on the SaPIbov5-encoded protein Ccm, a homolog of the varphi12 capsid protein (CP). Using cryo-electron microscopy, we have determined structures of prolate varphi12 procapsids and isometric SaPIbov5 procapsids. varphi12 procapsids have icosahedral end caps with T(end) = 4 architecture and a T(mid) = 14 cylindrical midsection, whereas SaPIbov5 procapsids have T = 4 icosahedral architecture. We built atomic models for CP and Ccm, and show that Ccm occupies the pentameric capsomers in the isometric SaPIbov5 procapsids, suggesting that preferential incorporation of Ccm pentamers prevents the cylindrical midsection from forming. Our results highlight that pirate elements have evolved diverse mechanisms to suppress phage multiplication, including the acquisition of phage capsid protein homologs. | ||
| + | |||
| + | Shape shifter: redirection of prolate phage capsid assembly by staphylococcal pathogenicity islands.,Hawkins NC, Kizziah JL, Penades JR, Dokland T Nat Commun. 2021 Nov 4;12(1):6408. doi: 10.1038/s41467-021-26759-x. PMID:34737316<ref>PMID:34737316</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7rwz" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Staphylococcus aureus]] |
| + | [[Category: Dokland T]] | ||
| + | [[Category: Hawkins NC]] | ||
| + | [[Category: Kizziah JL]] | ||
Current revision
SaPIbov5 procapsid structure including size redirecting protein Ccm
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