7rze
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7rze]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RZE FirstGlance]. <br> | <table><tr><td colspan='2'>[[7rze]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RZE FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rze OCA], [https://pdbe.org/7rze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rze RCSB], [https://www.ebi.ac.uk/pdbsum/7rze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rze ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rze OCA], [https://pdbe.org/7rze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rze RCSB], [https://www.ebi.ac.uk/pdbsum/7rze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rze ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |
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| + | ==See Also== | ||
| + | *[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Insulin Degrading Enzyme pO/pC
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