7sn9

<table><tr><td colspan='2'>[[7sn9]] is a 42 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SN9 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sn9 OCA], [https://pdbe.org/7sn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sn9 RCSB], [https://www.ebi.ac.uk/pdbsum/7sn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sn9 ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/FLAA_RHIML FLAA_RHIML]] Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Homomer of FlaA is able to form a functional filament.

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== Publication Abstract from PubMed ==

Flagellar filaments function as the propellers of the bacterial flagellum and their supercoiling is key to motility. The outer domains on the surface of the filament are non-critical for motility in many bacteria and their structures and functions are not conserved. Here, we show the atomic cryo-electron microscopy structures for flagellar filaments from enterohemorrhagic Escherichia coli O157:H7, enteropathogenic E. coli O127:H6, Achromobacter, and Sinorhizobium meliloti, where the outer domains dimerize or tetramerize to form either a sheath or a screw-like surface. These dimers are formed by 180 degrees rotations of half of the outer domains. The outer domain sheath (ODS) plays a role in bacterial motility by stabilizing an intermediate waveform and prolonging the tumbling of E. coli cells. Bacteria with these ODS and screw-like flagellar filaments are commonly found in soil and human intestinal environments of relatively high viscosity suggesting a role for the dimerization in these environments.

 

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== References ==

[[Category: Egelman, E H]]

[[Category: Kreutzberger, M A.B]]

[[Category: Scharf, B E]]

[[Category: Structural protein]]