1w7x
From Proteopedia
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==Overview== | ==Overview== | ||
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere, with the coagulation cascade by selective inhibition of the extrinsic, pathway. | We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere, with the coagulation cascade by selective inhibition of the extrinsic, pathway. | ||
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| + | ==Disease== | ||
| + | Known diseases associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:47:42 2007'' |
Revision as of 17:41, 12 November 2007
|
FACTOR7- 413 COMPLEX
Contents |
Overview
We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere, with the coagulation cascade by selective inhibition of the extrinsic, pathway.
Disease
Known diseases associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]
About this Structure
1W7X is a Protein complex structure of sequences from Homo sapiens with CA, SO4, 413 and GOL as ligands. Active as Coagulation factor VIIa, with EC number 3.4.21.21 Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors., Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:16213138
Page seeded by OCA on Mon Nov 12 19:47:42 2007
Categories: Coagulation factor VIIa | Homo sapiens | Protein complex | Ackermann, J. | Alig, L. | Banner, D.W. | Boehm, H.J. | Groebke-Zbinden, K. | Hilpert, K. | Kuehne, H. | Lave, T. | Obst-Sander, U. | Riederer, M. | Stahl, M. | Tschopp, T.B. | Weber, L. | Wessel, H.P. | 413 | CA | GOL | SO4 | Coagulation | Enzyme complex | Serine protease
