Complement C3
From Proteopedia
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*'''C3a''' is a mediator of local inflammatory processes. | *'''C3a''' is a mediator of local inflammatory processes. | ||
*'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates. | *'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates. | ||
| - | *'''C3d''' is a fragment generated by C3b(residues 996-1287) which binds to antigens enhancing their uptake by B cells. | ||
*'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref> | *'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref> | ||
| + | *'''C3d''' is a fragment generated by C3b(residues 996-1287) which binds to antigens enhancing their uptake by B cells<ref>PMID:17337780</ref>. | ||
<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>. | <scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>. | ||
Current revision
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References
- ↑ Sahu A, Lambris JD. Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunol Rev. 2001 Apr;180:35-48. PMID:11414361
- ↑ Toapanta FR, Ross TM. Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity. Immunol Res. 2006;36(1-3):197-210. PMID:17337780 doi:10.1385/IR:36:1:197
- ↑ Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M. Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature. 2006 Nov 9;444(7116):217-20. Epub 2006 Oct 15. PMID:17051150 doi:10.1038/nature05263
