Contactin

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== Function ==
== Function ==
'''Contactin''' (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems<ref>PMID:16029194</ref>.
'''Contactin''' (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems<ref>PMID:16029194</ref>.
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'''Contactin-2''' is a synaptic membrane protein<ref>PMID:16029194</ref>.
== Disease ==
== Disease ==

Revision as of 07:11, 9 June 2024

Mouse contactin-3 domains Ig1-Ig4 complex with glycerol (PDB code 5i99)

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3D structures of contactin

Updated on 09-June-2024

References

  1. Rush AM, Craner MJ, Kageyama T, Dib-Hajj SD, Waxman SG, Ranscht B. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci. 2005 Jul;22(1):39-49. PMID:16029194 doi:http://dx.doi.org/10.1111/j.1460-9568.2005.04186.x
  2. Rush AM, Craner MJ, Kageyama T, Dib-Hajj SD, Waxman SG, Ranscht B. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci. 2005 Jul;22(1):39-49. PMID:16029194 doi:http://dx.doi.org/10.1111/j.1460-9568.2005.04186.x
  3. Cottrell CE, Bir N, Varga E, Alvarez CE, Bouyain S, Zernzach R, Thrush DL, Evans J, Trimarchi M, Butter EM, Cunningham D, Gastier-Foster JM, McBride KL, Herman GE. Contactin 4 as an autism susceptibility locus. Autism Res. 2011 Jun;4(3):189-99. doi: 10.1002/aur.184. Epub 2011 Feb 9. PMID:21308999 doi:http://dx.doi.org/10.1002/aur.184

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Michal Harel

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