CXC chemokine receptor
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
| - | '''CXC chemokine receptors''' bind to cytokines of the CXC chemokine family. '''CXCR4''' is specific for [[Stromal Derived Factor 1]] (SDF-1α, known also as CXCL12) | + | '''CXC chemokine receptors''' bind to cytokines of the CXC chemokine family. '''CXCR4''' is specific for [[Stromal Derived Factor 1]] (SDF-1α, known also as CXCL12). |
*'''CXCR1''' recognizes CXC chemokines with ELR amino acids adjacent to the C-terminal CXC motif.<ref>PMID:23086146</ref> | *'''CXCR1''' recognizes CXC chemokines with ELR amino acids adjacent to the C-terminal CXC motif.<ref>PMID:23086146</ref> | ||
*'''CXCR2''' is a critical mediator of neutrophil-mediated host defense in ''Pseudomonas'' pneumonia.<ref>PMID:10858247</ref> | *'''CXCR2''' is a critical mediator of neutrophil-mediated host defense in ''Pseudomonas'' pneumonia.<ref>PMID:10858247</ref> | ||
| + | *'''CXCR4''' is used by HIV to infect CD4+ T cells. The biological unit probably is a <scene name='56/566486/Cv/1'>dimer</scene> <ref>PMID:20929726</ref>. | ||
<scene name='43/438522/Cv/10'>Ligand binding cavity with antagonist citrulline</scene> (PDB code [[3oe0]]). | <scene name='43/438522/Cv/10'>Ligand binding cavity with antagonist citrulline</scene> (PDB code [[3oe0]]). | ||
Revision as of 09:27, 9 June 2024
| |||||||||||
3D Structures of CXC chemokine receptor
Updated on 09-June-2024
References
- ↑ Park SH, Das BB, Casagrande F, Tian Y, Nothnagel HJ, Chu M, Kiefer H, Maier K, De Angelis AA, Marassi FM, Opella SJ. Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature. 2012 Nov 29;491(7426):779-83. doi: 10.1038/nature11580. Epub 2012 Oct 21. PMID:23086146 doi:http://dx.doi.org/10.1038/nature11580
- ↑ Tsai WC, Strieter RM, Mehrad B, Newstead MW, Zeng X, Standiford TJ. CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect Immun. 2000 Jul;68(7):4289-96. doi: 10.1128/IAI.68.7.4289-4296.2000. PMID:10858247 doi:http://dx.doi.org/10.1128/IAI.68.7.4289-4296.2000
- ↑ Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science. 2010 Oct 7. PMID:20929726 doi:10.1126/science.1194396
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
