1smz
From Proteopedia
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'''Structure of Transportan in phospholipid bicellar solution''' | '''Structure of Transportan in phospholipid bicellar solution''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMZ OCA]. | |
==Reference== | ==Reference== | ||
NMR solution structure and position of transportan in neutral phospholipid bicelles., Barany-Wallje E, Andersson A, Graslund A, Maler L, FEBS Lett. 2004 Jun 4;567(2-3):265-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15178334 15178334] | NMR solution structure and position of transportan in neutral phospholipid bicelles., Barany-Wallje E, Andersson A, Graslund A, Maler L, FEBS Lett. 2004 Jun 4;567(2-3):265-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15178334 15178334] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Andersson, A.]] | [[Category: Andersson, A.]] | ||
[[Category: Barany-Wallje, E.]] | [[Category: Barany-Wallje, E.]] | ||
[[Category: Graslund, A.]] | [[Category: Graslund, A.]] | ||
[[Category: Maler, L.]] | [[Category: Maler, L.]] | ||
| - | [[Category: | + | [[Category: Transport protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:54:26 2008'' | |
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Revision as of 05:54, 3 May 2008
Structure of Transportan in phospholipid bicellar solution
Overview
Transportan is a chimeric cell-penetrating peptide constructed from the peptides galanin and mastoparan, which has the ability to internalize living cells carrying a hydrophilic load. In this study, we have determined the NMR solution structure and investigated the position of transportan in neutral bicelles. The structure revealed a well-defined alpha-helix in the C-terminal mastoparan part of the peptide and a weaker tendency to form an alpha-helix in the N-terminal domain. The position of the peptide in relation to the membrane, as studied by adding paramagnetic probes, shows that the peptide lies parallel to, and in the head-group region of the membrane surface. This result is supported by amide proton secondary chemical shifts.
About this Structure
Full crystallographic information is available from OCA.
Reference
NMR solution structure and position of transportan in neutral phospholipid bicelles., Barany-Wallje E, Andersson A, Graslund A, Maler L, FEBS Lett. 2004 Jun 4;567(2-3):265-9. PMID:15178334 Page seeded by OCA on Sat May 3 08:54:26 2008
