Cyclophilin

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*'''Cyclophilin-A''' has peptide cis-trans isomerase activity which regulates protein folding and trafficking<ref>PMID:24176846</ref> .
*'''Cyclophilin-A''' has peptide cis-trans isomerase activity which regulates protein folding and trafficking<ref>PMID:24176846</ref> .
*'''Cyclophilin-B''' interacts with HCV RNA polymerase and stimulates its RNA binding activity<ref>PMID:15989969</ref> .
*'''Cyclophilin-B''' interacts with HCV RNA polymerase and stimulates its RNA binding activity<ref>PMID:15989969</ref> .
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*'''Cyclophilin-C''' is a component of US2-mediated immune invasion<ref>PMID:26691022</ref> .
== Relevance ==
== Relevance ==

Revision as of 10:21, 10 June 2024

Human Cyclophilin-A (rust, olive, turquois, dark green, khaki) complex with cyclosporin A (green, cyan, aqua, neon green, blue) (PDB entry 2x2c)

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References

  1. ↑ Stamnes MA, Rutherford SL, Zuker CS. Cyclophilins: a new family of proteins involved in intracellular folding. Trends Cell Biol. 1992 Sep;2(9):272-6. PMID:14731520
  2. ↑ Nigro P, Pompilio G, Capogrossi MC. Cyclophilin A: a key player for human disease. Cell Death Dis. 2013 Oct 31;4(10):e888. PMID:24176846 doi:10.1038/cddis.2013.410
  3. ↑ Watashi K, Ishii N, Hijikata M, Inoue D, Murata T, Miyanari Y, Shimotohno K. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. Mol Cell. 2005 Jul 1;19(1):111-22. PMID:15989969 doi:10.1016/j.molcel.2005.05.014
  4. ↑ Chapman DC, Stocki P, Williams DB. Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules. PLoS One. 2015 Dec 21;10(12):e0145458. PMID:26691022 doi:10.1371/journal.pone.0145458
  5. ↑ Zhou D, Mei Q, Li J, He H. Cyclophilin A and viral infections. Biochem Biophys Res Commun. 2012 Aug 10;424(4):647-50. doi:, 10.1016/j.bbrc.2012.07.024. Epub 2012 Jul 16. PMID:22814107 doi:http://dx.doi.org/10.1016/j.bbrc.2012.07.024
  6. ↑ Hatziioannou T, Perez-Caballero D, Cowan S, Bieniasz PD. Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells. J Virol. 2005 Jan;79(1):176-83. PMID:15596813 doi:http://dx.doi.org/10.1128/JVI.79.1.176-183.2005
  7. ↑ Lammers M, Neumann H, Chin JW, James LC. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nat Chem Biol. 2010 May;6(5):331-7. Epub 2010 Apr 4. PMID:20364129 doi:10.1038/nchembio.342

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