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1snk

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[[Image:1snk.gif|left|200px]]
[[Image:1snk.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1snk |SIZE=350|CAPTION= <scene name='initialview01'>1snk</scene>, resolution 2.40&Aring;
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The line below this paragraph, containing "STRUCTURE_1snk", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MYE:N2-({[(4-BROMOPHENYL)METHYL]OXY}CARBONYL)-N1-[(1S)-1-FORMYLPENTYL]-L-LEUCINAMIDE'>MYE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1snk| PDB=1snk | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1snk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1snk OCA], [http://www.ebi.ac.uk/pdbsum/1snk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1snk RCSB]</span>
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}}
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'''Cathepsin K complexed with carbamate derivatized norleucine aldehyde'''
'''Cathepsin K complexed with carbamate derivatized norleucine aldehyde'''
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[[Category: Thompson, J B.]]
[[Category: Thompson, J B.]]
[[Category: Wright, L L.]]
[[Category: Wright, L L.]]
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[[Category: catk]]
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[[Category: Catk]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:55:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:44:31 2008''
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Revision as of 05:55, 3 May 2008

Image:1snk.gif

Template:STRUCTURE 1snk

Cathepsin K complexed with carbamate derivatized norleucine aldehyde


Overview

The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S2 and S3 subsites with a series of carbamate derivatized norleucine aldehydes substituted at the P2 and P3 positions afforded analogs with cathepsin K IC50s between 600 nM and 130 pM.

About this Structure

1SNK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors., Boros EE, Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Paulick MG, Shewchuk LM, Thompson JB, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2004 Jul 5;14(13):3425-9. PMID:15177446 Page seeded by OCA on Sat May 3 08:55:25 2008

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