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1soo
From Proteopedia
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[[Image:1soo.jpg|left|200px]] | [[Image:1soo.jpg|left|200px]] | ||
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'''ADENYLOSUCCINATE SYNTHETASE INHIBITED BY HYDANTOCIDIN 5'-MONOPHOSPHATE''' | '''ADENYLOSUCCINATE SYNTHETASE INHIBITED BY HYDANTOCIDIN 5'-MONOPHOSPHATE''' | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Cowan-Jacob, S W.]] | [[Category: Cowan-Jacob, S W.]] | ||
| - | [[Category: | + | [[Category: Gtp-hydrolyzing enzyme]] |
| - | [[Category: | + | [[Category: Herbicide]] |
| - | [[Category: | + | [[Category: Ligase]] |
| - | [[Category: | + | [[Category: Purine nucleotide biosynthesis]] |
| - | [[Category: | + | [[Category: Synthetase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:57:34 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:57, 3 May 2008
ADENYLOSUCCINATE SYNTHETASE INHIBITED BY HYDANTOCIDIN 5'-MONOPHOSPHATE
Overview
(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine synthesis. The mode of binding of hydantocidin 5'-monophosphate to the target enzyme was analyzed by determining the crystal structure of the enzyme-inhibitor complex at 2.6-A resolution. It was found that adenylosuccinate synthetase binds the phosphorylated compound in the same fashion as it does adenosine 5'-monophosphate, the natural feedback regulator of this enzyme. This work provides the first crystal structure of a herbicide-target complex reported to date.
About this Structure
1SOO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase., Fonne-Pfister R, Chemla P, Ward E, Girardet M, Kreuz KE, Honzatko RB, Fromm HJ, Schar HP, Grutter MG, Cowan-Jacob SW, Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9431-6. PMID:8790347 Page seeded by OCA on Sat May 3 08:57:34 2008
