DnaJ homolog

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'''DnaJ homolog subfamily B member 1''' (DnaJB1) interacts with HSP70. DnaJB1 stimulates ATP synthesis and the folding of unfolded proteins mediated by HSPA1A <ref>PMID:24318877</ref>.<br />
'''DnaJ homolog subfamily B member 1''' (DnaJB1) interacts with HSP70. DnaJB1 stimulates ATP synthesis and the folding of unfolded proteins mediated by HSPA1A <ref>PMID:24318877</ref>.<br />
'''DnaJ homolog subfamily B member 6''' (DnaJB6) acts as co-chaperone of HSP70. <ref>PMID:10954706</ref>.<br />
'''DnaJ homolog subfamily B member 6''' (DnaJB6) acts as co-chaperone of HSP70. <ref>PMID:10954706</ref>.<br />
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'''DnaJ homolog subfamily C member 2''' (DnaJC2) acts as a chaperone for nascent polypeptide chains exiting the ribosome.
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'''DnaJ homolog subfamily C member 2''' (DnaJC2) acts as a chaperone for nascent polypeptide chains exiting the ribosome.<br />
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'''DnaJ homolog subfamily C member 3''' (DnaJC3) acts as an inhibitor of the interferon-induced dsRNA-activated protein kinase.
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'''DnaJ homolog subfamily C member 3''' (DnaJC3) acts as an inhibitor of the interferon-induced dsRNA-activated protein kinase.<br />
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'''DnaJ homolog subfamily C member 5''' (DnaJC5) acts in membrane trafficking and protein folding,.
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'''DnaJ homolog subfamily C member 5''' (DnaJC5) acts in membrane trafficking and protein folding.<br />
== Disease ==
== Disease ==

Revision as of 08:06, 16 June 2024

Human DnaJ homolog subfamity B member 1 peptide-binding domain dimer (cyan and green) complex with 3 C-terminal peptides of heat shock protein 70 (pink, magenta, violet) (PDB code 3agy)

Drag the structure with the mouse to rotate

References

  1. ↑ Terada K, Mori M. Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. J Biol Chem. 2000 Aug 11;275(32):24728-34. PMID:10816573 doi:http://dx.doi.org/10.1074/jbc.M002021200
  2. ↑ Rauch JN, Gestwicki JE. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014 Jan 17;289(3):1402-14. doi: 10.1074/jbc.M113.521997. Epub 2013 , Dec 5. PMID:24318877 doi:http://dx.doi.org/10.1074/jbc.M113.521997
  3. ↑ Izawa I, Nishizawa M, Ohtakara K, Ohtsuka K, Inada H, Inagaki M. Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein. J Biol Chem. 2000 Nov 3;275(44):34521-7. PMID:10954706 doi:http://dx.doi.org/10.1074/jbc.M003492200
  4. ↑ Stark JL, Mehla K, Chaika N, Acton TB, Xiao R, Singh PK, Montelione GT, Powers R. Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry. 2014 Mar 4;53(8):1360-72. doi: 10.1021/bi401329a. Epub 2014 Feb 19. PMID:24512202 doi:http://dx.doi.org/10.1021/bi401329a
  5. ↑ Suzuki H, Noguchi S, Arakawa H, Tokida T, Hashimoto M, Satow Y. Peptide-binding sites as revealed by the crystal structures of the human Hsp40 Hdj1 C-terminal domain in complex with the octapeptide from human Hsp70. Biochemistry. 2010 Oct 5;49(39):8577-84. Epub 2010 Sep 9. PMID:20809635 doi:10.1021/bi100876n

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Michal Harel, Alexander Berchansky

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