Ephrin receptor

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== Function ==
== Function ==
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'''Ephrin receptors''' (EPHR) are components of the cell signaling pathways. They belong to the [[receptor tyrosine kinases]]. The extracellular ligand-binding domain (LBD) interacts with ephrin<ref>PMID:21078817</ref>. For more details see [[Ephrin Type-A Receptor]] and [[Kinase-linked, enzyme-linked and related receptors]].
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'''Ephrin receptors''' (EPHR) are components of the cell signaling pathways. They belong to the [[receptor tyrosine kinases]]. The extracellular ligand-binding domain (LBD) interacts with ephrin<ref>PMID:21078817</ref>.
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*'''Ephrin receptor A2''' functions in entry of Epstein-
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For more details see [[Ephrin Type-A Receptor]] and [[Kinase-linked, enzyme-linked and related receptors]].
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Revision as of 09:37, 18 June 2024

Human ephrin A3 receptor (magenta) complex with peptide substrate (green), nucleotide derivative and Mg+2 ion 3fxx

Drag the structure with the mouse to rotate

References

  1. Pitulescu ME, Adams RH. Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev. 2010 Nov 15;24(22):2480-92. doi: 10.1101/gad.1973910. PMID:21078817 doi:http://dx.doi.org/10.1101/gad.1973910
  2. Genander M, Frisen J. Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol. 2010 Oct;22(5):611-6. doi: 10.1016/j.ceb.2010.08.005. PMID:20810264 doi:http://dx.doi.org/10.1016/j.ceb.2010.08.005
  3. Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. FEBS J. 2009 Aug;276(16):4395-404. PMID:19678838 doi:http://dx.doi.org/10.1111/j.1742-4658.2009.07147.x

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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