Ephrin receptor

From Proteopedia

Revision as of 10:09, 18 June 2024

spinqualitylabelsall models Human ephrin A3 receptor (magenta) complex with peptide substrate (green), nucleotide derivative and Mg+2 ion 3fxx Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Relevance 3 Structural highlights 4 3D Structures of ephrin receptor Function Ephrin receptors (EPHR) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin[1]. Ephrin receptor A2 functions in entry of Epstein-Barr virus to epithelial cells[2]. Ephrin receptor A4 functions in entry of Kaposi's sarcoma-associated herpesvirus to cells[3]. For more details see Ephrin Type-A Receptor and Kinase-linked, enzyme-linked and related receptors. . Relevance EPHR and ephrins can act as both tumor suppressors and tumor enhancers depending on the context[4]. Structural highlights EPHR domains include an ectodomain (residues 23-435) containing the LBD (residues 23-326), a second fibronectin III domain (fn3) (residues 446-539), a transmembrane domain (residues 539-563), a kinase domain (residues 596-900) and a sterile-α-motif (SAM) domain (residues 908-972). . Water molecules are shown as red spheres. . (3fxx).[5] 3D Structures of ephrin receptor Ephrin receptor 3D structures

References

1. ↑ Pitulescu ME, Adams RH. Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev. 2010 Nov 15;24(22):2480-92. doi: 10.1101/gad.1973910. PMID:21078817 doi:http://dx.doi.org/10.1101/gad.1973910
2. ↑ Chen J, Sathiyamoorthy K, Zhang X, Schaller S, Perez White BE, Jardetzky TS, Longnecker R. Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus. Nat Microbiol. 2018 Feb;3(2):172-180. PMID:29292384 doi:10.1038/s41564-017-0081-7
3. ↑ Chen J, Zhang X, Schaller S, Jardetzky TS, Longnecker R. Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor. mBio. 2019 Feb 19;10(1):e02892-18. PMID:30782663 doi:10.1128/mBio.02892-18
4. ↑ Genander M, Frisen J. Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol. 2010 Oct;22(5):611-6. doi: 10.1016/j.ceb.2010.08.005. PMID:20810264 doi:http://dx.doi.org/10.1016/j.ceb.2010.08.005
5. ↑ Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. FEBS J. 2009 Aug;276(16):4395-404. PMID:19678838 doi:http://dx.doi.org/10.1111/j.1742-4658.2009.07147.x