1wcy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1wcy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wcy, resolution 2.2&Aring;" /> '''Crystal Structure Of...)
Next diff →

Revision as of 17:42, 12 November 2007

Image:1wcy.gif

1wcy, resolution 2.2Å

Drag the structure with the mouse to rotate

Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A

Overview

Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the, prolyl oligopeptidase (POP) family, and has been implicated in several, diseases. Therefore, it seems important to develop selective inhibitors, for human DPPIV (hDPPIV) that are able to control the biological function, of hDPPIV. In order to elucidate the binding mode and substrate, specificity, we determined the crystal structure complex of hDPPIV and, diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2, A resolution. In this paper, we discuss the molecular interaction, mechanism of diprotin A with hDPPIV based on the X-ray crystal structure.

About this Structure

1WCY is a Single protein structure of sequence from Homo sapiens with NAG as ligand. Active as Dipeptidyl-peptidase IV, with EC number 3.4.14.5 Full crystallographic information is available from OCA.

Reference

The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A., Hiramatsu H, Yamamoto A, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Shimizu R, Biol Chem. 2004 Jun;385(6):561-4. PMID:15255191

Page seeded by OCA on Mon Nov 12 19:49:13 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wcy"
Personal tools