8y66

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Current revision (05:56, 19 June 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8y66 is ON HOLD until Paper Publication
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==Cryo-EM structure of human urate transporter GLUT9 bound to inhibitor apigenin==
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<StructureSection load='8y66' size='340' side='right'caption='[[8y66]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8y66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y66 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.28&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGI:5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE'>AGI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y66 OCA], [https://pdbe.org/8y66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y66 RCSB], [https://www.ebi.ac.uk/pdbsum/8y66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y66 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GTR9_HUMAN GTR9_HUMAN] Hereditary renal hypouricemia. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/GTR9_HUMAN GTR9_HUMAN] High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:18701466, PubMed:22647630, PubMed:28083649, PubMed:36749388). May have a residual high-affinity, low-capacity glucose and fructose transporter activity (PubMed:18327257, PubMed:18701466, PubMed:18842065). Transports urate at rates 45- to 60-fold faster than glucose (PubMed:18842065). Does not transport galactose (PubMed:28083649). May mediate small uptake of adenine but not of other nucleobases (PubMed:22647630).<ref>PMID:18327257</ref> <ref>PMID:18701466</ref> <ref>PMID:18842065</ref> <ref>PMID:22647630</ref> <ref>PMID:28083649</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Huang GXY]]
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[[Category: Pan XJ]]
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[[Category: Shen ZL]]
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[[Category: Xu L]]

Current revision

Cryo-EM structure of human urate transporter GLUT9 bound to inhibitor apigenin

PDB ID 8y66

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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