8zm2

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Current revision (05:57, 19 June 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8zm2 is ON HOLD until Paper Publication
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==Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 16==
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<StructureSection load='8zm2' size='340' side='right'caption='[[8zm2]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8zm2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZM2 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L17:methyl+(9~{R})-9-oxidanyl-9-(trifluoromethyl)fluorene-4-carboxylate'>A1L17</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zm2 OCA], [https://pdbe.org/8zm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zm2 RCSB], [https://www.ebi.ac.uk/pdbsum/8zm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zm2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDK2_HUMAN PDK2_HUMAN] Serine/threonine kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.<ref>PMID:7499431</ref> <ref>PMID:9787110</ref> <ref>PMID:17222789</ref> <ref>PMID:19833728</ref> <ref>PMID:21283817</ref> <ref>PMID:22123926</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Adachi T]]
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[[Category: Akai S]]
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[[Category: Nomura A]]
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[[Category: Orita T]]

Current revision

Structure of human pyruvate dehydrogenase kinase 2 complexed with compound 16

PDB ID 8zm2

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OCA

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