1sqj

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[[Image:1sqj.gif|left|200px]]
[[Image:1sqj.gif|left|200px]]
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{{Structure
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|PDB= 1sqj |SIZE=350|CAPTION= <scene name='initialview01'>1sqj</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1sqj", creates the "Structure Box" on the page.
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|SITE=
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Oligoxyloglucan_reducing-end-specific_cellobiohydrolase Oligoxyloglucan reducing-end-specific cellobiohydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.150 3.2.1.150] </span>
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{{STRUCTURE_1sqj| PDB=1sqj | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqj OCA], [http://www.ebi.ac.uk/pdbsum/1sqj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sqj RCSB]</span>
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'''Crystal Structure Analysis of Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH)'''
'''Crystal Structure Analysis of Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH)'''
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[[Category: Tsuda, S.]]
[[Category: Tsuda, S.]]
[[Category: Yaoi, K.]]
[[Category: Yaoi, K.]]
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[[Category: beta-propeller]]
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[[Category: Beta-propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:01:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:45:38 2008''
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Revision as of 06:01, 3 May 2008

Image:1sqj.gif

Template:STRUCTURE 1sqj

Crystal Structure Analysis of Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH)


Overview

Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH; EC 3.2.1.150) is an exoglucanase that recognizes the reducing end of oligoxyloglucan and releases two glucosyl residue segments from the main chain. The X-ray crystal structure of OXG-RCBH determined at 2.2 A resolution reveals a unique feature of this enzyme; OXG-RCBH consists of a tandem repeat of two similar domains, which are both folded into seven-bladed beta-propeller structures. The sequence alignment of the propeller blades, based on the structure, indicates that a weak repeat of the amino acid sequence occurred seven times to construct each domain. There is a cleft that can accommodate the substrate oligosaccharide between the two domains, which is a putative substrate binding subsite. Mutation of either Asp35 or Asp465, located in the putative catalytic center, to Asn resulted in a protein with no detectable catalytic activity, indicating the critical role of these amino acids in catalysis.

About this Structure

1SQJ is a Single protein structure of sequence from Geotrichum sp. m128. Full crystallographic information is available from OCA.

Reference

Tandem repeat of a seven-bladed beta-propeller domain in oligoxyloglucan reducing-end-specific cellobiohydrolase., Yaoi K, Kondo H, Noro N, Suzuki M, Tsuda S, Mitsuishi Y, Structure. 2004 Jul;12(7):1209-17. PMID:15242597 Page seeded by OCA on Sat May 3 09:01:23 2008

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