6y3k

<table><tr><td colspan='2'>[[6y3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corylus_avellana Corylus avellana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y3K FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y3k OCA], [https://pdbe.org/6y3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y3k RCSB], [https://www.ebi.ac.uk/pdbsum/6y3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y3k ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/Q9FPK3_CORAV Q9FPK3_CORAV]

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== Publication Abstract from PubMed ==

A major proportion of allergic reactions to hazelnuts (Corylus avellana) are caused by immunologic cross-reactivity of IgE antibodies to pathogenesis-related class 10 (PR-10) proteins. Intriguingly, the four known isoforms of the hazelnut PR-10 allergen Cor a 1, denoted as Cor a 1.0401-Cor a 1.0404, share sequence identities exceeding 97% but possess different immunologic properties. In this work we describe the NMR solution structures of these proteins and provide an in-depth study of their biophysical properties. Despite sharing highly similar three-dimensional structures, the four isoforms exhibit remarkable differences regarding structural flexibility, hydrogen bonding and thermal stability. Our experimental data reveal an inverse relation between structural flexibility and IgE-binding in ELISA experiments, with the most flexible isoform having the lowest IgE-binding potential, while the isoform with the most rigid backbone scaffold displays the highest immunologic reactivity. These results point towards a significant entropic contribution to the process of antibody binding.

Inverse relation between structural flexibility and IgE reactivity of Cor a 1 hazelnut allergens.,Fuhrer S, Kamenik AS, Zeindl R, Nothegger B, Hofer F, Reider N, Liedl KR, Tollinger M Sci Rep. 2021 Feb 18;11(1):4173. doi: 10.1038/s41598-021-83705-z. PMID:33603065<ref>PMID:33603065</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Corylus avellana]]