6zv1

<table><tr><td colspan='2'>[[6zv1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV1 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv1 OCA], [https://pdbe.org/6zv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv1 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv1 ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/IWS1_HUMAN IWS1_HUMAN] Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.<ref>PMID:17184735</ref> <ref>PMID:17234882</ref> <ref>PMID:19141475</ref>

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== Publication Abstract from PubMed ==

[Figure: see text].

A ubiquitous disordered protein interaction module orchestrates transcription elongation.,Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V Science. 2021 Nov 26;374(6571):1113-1121. doi: 10.1126/science.abe2913. Epub 2021, Nov 25. PMID:34822292<ref>PMID:34822292</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Homo sapiens]]