6zv3

<table><tr><td colspan='2'>[[6zv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZV3 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zv3 OCA], [https://pdbe.org/6zv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zv3 RCSB], [https://www.ebi.ac.uk/pdbsum/6zv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zv3 ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/MED26_HUMAN MED26_HUMAN] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.

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== Publication Abstract from PubMed ==

[Figure: see text].

A ubiquitous disordered protein interaction module orchestrates transcription elongation.,Cermakova K, Demeulemeester J, Lux V, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V Science. 2021 Nov 26;374(6571):1113-1121. doi: 10.1126/science.abe2913. Epub 2021, Nov 25. PMID:34822292<ref>PMID:34822292</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Homo sapiens]]