7pgf

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<StructureSection load='7pgf' size='340' side='right'caption='[[7pgf]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='7pgf' size='340' side='right'caption='[[7pgf]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7pgf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PGF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7pgf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ruegeria_pomeroyi Ruegeria pomeroyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PGF FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7pgp|7pgp]], [[7pg8|7pg8]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pgf OCA], [https://pdbe.org/7pgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pgf RCSB], [https://www.ebi.ac.uk/pdbsum/7pgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pgf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pgf OCA], [https://pdbe.org/7pgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pgf RCSB], [https://www.ebi.ac.uk/pdbsum/7pgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pgf ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/F7IVA8_RUEPO F7IVA8_RUEPO]
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Every voltage-gated ion channel (VGIC) has a pore domain (PD) made from four subunits, each comprising an antiparallel transmembrane helix pair bridged by a loop. The extent to which PD subunit structure requires quaternary interactions is unclear. Here, we present crystal structures of a set of bacterial voltage-gated sodium channel (BacNaV) 'pore only' proteins that reveal a surprising collection of non-canonical quaternary arrangements in which the PD tertiary structure is maintained. This context-independent structural robustness, supported by molecular dynamics simulations, indicates that VGIC-PD tertiary structure is independent of quaternary interactions. This fold occurs throughout the VGIC superfamily and in diverse transmembrane and soluble proteins. Strikingly, characterization of PD subunit-binding Fabs indicates that non-canonical quaternary PD conformations can occur in full-length VGICs. Together, our data demonstrate that the VGIC-PD is an autonomously folded unit. This property has implications for VGIC biogenesis, understanding functional states, de novo channel design, and VGIC structural origins.
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Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.,Arrigoni C, Lolicato M, Shaya D, Rohaim A, Findeisen F, Fong LK, Colleran CM, Dominik P, Kim SS, Schuermann JP, DeGrado WF, Grabe M, Kossiakoff AA, Minor DL Jr Nat Struct Mol Biol. 2022 Jun 2. pii: 10.1038/s41594-022-00775-x. doi:, 10.1038/s41594-022-00775-x. PMID:35655098<ref>PMID:35655098</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7pgf" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrigoni, C]]
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[[Category: Ruegeria pomeroyi]]
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[[Category: Lolicato, M]]
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[[Category: Arrigoni C]]
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[[Category: Ion channel membrane protein transport protein antibody complex]]
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[[Category: Lolicato M]]
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[[Category: Membrane protein]]
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Current revision

Calcium-selective Sp1 channel pore domain only

PDB ID 7pgf

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