7vci

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7vci]] is a 19 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VCI FirstGlance]. <br>
<table><tr><td colspan='2'>[[7vci]] is a 19 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VCI FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vci OCA], [https://pdbe.org/7vci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vci RCSB], [https://www.ebi.ac.uk/pdbsum/7vci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vci ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vci OCA], [https://pdbe.org/7vci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vci RCSB], [https://www.ebi.ac.uk/pdbsum/7vci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vci ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NUP85_XENLA NUP85_XENLA]] Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Involved in nephrogenesis (By similarity).[UniProtKB:Q6DK84][UniProtKB:Q9BW27]
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[https://www.uniprot.org/uniprot/NUP85_XENLA NUP85_XENLA] Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Involved in nephrogenesis (By similarity).[UniProtKB:Q6DK84][UniProtKB:Q9BW27]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The nuclear pore complex (NPC), one of the largest protein complexes in eukaryotes, serves as a physical gate to regulate nucleocytoplasmic transport. Here, we determined the 8 A resolution cryo-electron microscopic (cryo-EM) structure of the outer rings containing nuclear ring (NR) and cytoplasmic ring (CR) from the Xenopus laevis NPC, with local resolutions reaching 4.9 A. With the aid of AlphaFold2, we managed to build a pseudoatomic model of the outer rings, including the Y complexes and flanking components. In this most comprehensive and accurate model of outer rings to date, the almost complete Y complex structure exhibits much tighter interaction in the hub region. In addition to two copies of Y complexes, each asymmetric subunit in CR contains five copies of Nup358, two copies of the Nup214 complex, two copies of Nup205 and one copy of newly identified Nup93, while that in NR contains one copy of Nup205, one copy of ELYS and one copy of Nup93. These in-depth structural features represent a great advance in understanding the assembly of NPCs.
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8 A structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI.,Tai L, Zhu Y, Ren H, Huang X, Zhang C, Sun F Protein Cell. 2022 Oct;13(10):760-777. doi: 10.1007/s13238-021-00895-y. Epub 2022, Jan 11. PMID:35015240<ref>PMID:35015240</ref>
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==See Also==
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7vci" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>

Current revision

Structure of Xenopus laevis NPC nuclear ring asymmetric unit

PDB ID 7vci

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