7ze0

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Current revision (06:23, 19 June 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7ze0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_oxytoca Klebsiella oxytoca]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZE0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7ze0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_oxytoca Klebsiella oxytoca]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZE0 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ze0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ze0 OCA], [https://pdbe.org/7ze0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ze0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ze0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ze0 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ze0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ze0 OCA], [https://pdbe.org/7ze0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ze0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ze0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ze0 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/GSPM_KLEPN GSPM_KLEPN] Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Plays a role in the complex assembly and recruits PulL resulting in a stable complex in the inner membrane. Provides thus a link between the energy-providing PulE protein in the cytoplasm and the rest of the T2SS machinery.[UniProtKB:P25061]
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Type II secretion systems (T2SSs) allow diderm bacteria to secrete hydrolytic enzymes, adhesins, or toxins important for growth and virulence. To promote secretion of folded proteins, T2SSs assemble periplasmic filaments called pseudopili or endopili at an inner membrane subcomplex, the assembly platform (AP). Here, we combined biophysical approaches, nuclear magnetic resonance (NMR) and X-ray crystallography, to study the Klebsiella AP components PulL and PulM. We determined the structure and associations of their periplasmic domains and describe the structure of the heterodimer formed by their ferredoxin-like domains. We show how structural complementarity and plasticity favor their association during the secretion process. Cysteine scanning and crosslinking data provided additional constraints to build a structural model of the PulL-PulM assembly in the cellular context. Our structural and functional insights, together with the relative cellular abundance of its components, support the role of AP as a dynamic hub that orchestrates pilus polymerization.
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Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.,Dazzoni R, Li Y, Lopez-Castilla A, Brier S, Mechaly A, Cordier F, Haouz A, Nilges M, Francetic O, Bardiaux B, Izadi-Pruneyre N Structure. 2022 Dec 16:S0969-2126(22)00489-0. doi: 10.1016/j.str.2022.12.003. PMID:36586404<ref>PMID:36586404</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7ze0" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>

Current revision

Solution structure of the PulM C-terminal domain from Klebsiella oxytoca

PDB ID 7ze0

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