8bny
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8bny]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BNY FirstGlance]. <br> | <table><tr><td colspan='2'>[[8bny]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BNY FirstGlance]. <br> | ||
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.429Å</td></tr> |
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bny OCA], [https://pdbe.org/8bny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bny RCSB], [https://www.ebi.ac.uk/pdbsum/8bny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bny ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bny OCA], [https://pdbe.org/8bny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bny RCSB], [https://www.ebi.ac.uk/pdbsum/8bny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bny ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/E9RIY8_BACNA E9RIY8_BACNA] | [https://www.uniprot.org/uniprot/E9RIY8_BACNA E9RIY8_BACNA] | ||
- | <div style="background-color:#fffaf0;"> | ||
- | == Publication Abstract from PubMed == | ||
- | Transcriptional regulation usually requires the action of several proteins that either repress or activate a promotor of an open reading frame. These proteins can counteract each other, thus allowing tight regulation of the transcription of the corresponding genes, where tight repression is often linked to DNA looping or cross-linking. Here, the tetramerization domain of the bacterial gene repressor Rco from Bacillus subtilis plasmid pLS20 (Rco(pLS20)) has been identified and its structure is shown to share high similarity to the tetramerization domain of the well known p53 family of human tumor suppressors, despite lacking clear sequence homology. In Rco(pLS20), this tetramerization domain is responsible for inducing DNA looping, a process that involves multiple tetramers. In accordance, it is shown that Rco(pLS20) can form octamers. This domain was named TetD(loop) and its occurrence was identified in other Bacillus species. The TetD(loop) fold was also found in the structure of a transcriptional repressor from Salmonella phage SPC32H. It is proposed that the TetD(loop) fold has evolved through divergent evolution and that the TetD(loop) originates from a common ancestor predating the occurrence of multicellular life. | ||
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- | A tetramerization domain in prokaryotic and eukaryotic transcription regulators homologous to p53.,Bernardo N, Crespo I, Cuppari A, Meijer WJJ, Boer DR Acta Crystallogr D Struct Biol. 2023 Mar 1;79(Pt 3):259-267. doi: , 10.1107/S2059798323001298. Epub 2023 Mar 1. PMID:36876435<ref>PMID:36876435</ref> | ||
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- | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
- | </div> | ||
- | <div class="pdbe-citations 8bny" style="background-color:#fffaf0;"></div> | ||
- | == References == | ||
- | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> |
Current revision
Structure of the tetramerization domain of pLS20 conjugation repressor Rco
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