8ci0
From Proteopedia
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/TKTC_MAIZE TKTC_MAIZE] | [https://www.uniprot.org/uniprot/TKTC_MAIZE TKTC_MAIZE] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | We report the design, synthesis and biological evaluation of simplified analogues of the herbicidal natural product (+)-cornexistin. Guided by an X-Ray co-crystal structure of cornexistin bound to the transketolase enzyme from Zea mays, we attempted to identify the key interactions that are necessary for cornexistin to maintain its herbicidal profile. This resulted in the preparation of three novel analogues investigating the importance of substituents that are located on the nine-membered ring of cornexistin. One analogue maintained a good level of biological activity and could provide researchers insights in how to further optimize the structure of cornexistin for commercialization in the future. | ||
| - | + | ==See Also== | |
| - | + | *[[Transketolase 3D structures|Transketolase 3D structures]] | |
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Maize Transketolase in complex with TPP and hydrolyzed (+)-Cornexistin
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