Journal:Acta Cryst D:S2059798324005461

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<StructureSection load='' size='450' side='right' scene='underdevelopment' caption=''>
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<StructureSection load='' size='450' side='right' scene='underdevelopment' caption=''>__NOTOC__
===Toward a dependable data set of structures for L-asparaginase===
===Toward a dependable data set of structures for L-asparaginase===
<big>Alexander Wlodawer, Zbigniew Dauter, Jacek Lubkowski, Joanna I. Loch, Dariusz Brzezinski, Miroslaw Gilski, Mariusz Jaskolski</big> <ref>doi: 10.1107/S2059798324005461</ref>
<big>Alexander Wlodawer, Zbigniew Dauter, Jacek Lubkowski, Joanna I. Loch, Dariusz Brzezinski, Miroslaw Gilski, Mariusz Jaskolski</big> <ref>doi: 10.1107/S2059798324005461</ref>
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<b>Molecular Tour</b><br>
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==Molecular Tour==
L-Asparaginase (ASNase) catalyzes the hydrolysis of L-Asn to L-Asp, according to the reaction:
L-Asparaginase (ASNase) catalyzes the hydrolysis of L-Asn to L-Asp, according to the reaction:
<b>ASNase + L-Asn + H2O → ASNase + L-Asp + NH3</b>
<b>ASNase + L-Asn + H2O → ASNase + L-Asp + NH3</b>
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Beyond pure academic curiosity, ASNases are also studied because of their potential application as first-line drugs for the treatment of acute lymphoblastic leukemia (ALL). Since the late 1970s, Class 1 type II L-asparaginases of bacterial origin have been used in the clinical treatment of ALL, and there are recent reports that ASNases could be effective against solid tumors as well. However, in view of the frequent severe side effects accompanying current administration protocols, it is not surprising that significant research effort has been directed into engineering the other types of ASNases into useful drugs. Thus, careful analysis of all known structures of ASNases, with the view of indicating enzymes with potential for becoming novel therapeutics, is still very important.
Beyond pure academic curiosity, ASNases are also studied because of their potential application as first-line drugs for the treatment of acute lymphoblastic leukemia (ALL). Since the late 1970s, Class 1 type II L-asparaginases of bacterial origin have been used in the clinical treatment of ALL, and there are recent reports that ASNases could be effective against solid tumors as well. However, in view of the frequent severe side effects accompanying current administration protocols, it is not surprising that significant research effort has been directed into engineering the other types of ASNases into useful drugs. Thus, careful analysis of all known structures of ASNases, with the view of indicating enzymes with potential for becoming novel therapeutics, is still very important.
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<b>Refined Structures</b><br>
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==Dependable Structures==
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<b>References</b><br>
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<text>dependable structure</text>
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<text>deposited structure</text>
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==References==
<references/>
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</StructureSection>
</StructureSection>
__NOEDITSECTION__
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Revision as of 14:42, 19 June 2024

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