Estrogen-related receptor
From Proteopedia
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'''Estrogen-related receptor''' (ERR) binds to estrogen response elements on DNA and modulates transcription in response to [[Hormone|hormone]]. It is a [[Nuclear receptors|nuclear receptor]]. There are 3 classes of ERR : ERRα, ERRβ and ERRγ. | '''Estrogen-related receptor''' (ERR) binds to estrogen response elements on DNA and modulates transcription in response to [[Hormone|hormone]]. It is a [[Nuclear receptors|nuclear receptor]]. There are 3 classes of ERR : ERRα, ERRβ and ERRγ. | ||
| + | *'''ERR alpha''' regulates cellular metabolism and function<ref>PMID:32121253</ref>. | ||
See also [[Intracellular receptors]] | See also [[Intracellular receptors]] | ||
Revision as of 09:21, 20 June 2024
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References
- ↑ Tripathi M, Yen PM, Singh BK. Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases. Int J Mol Sci. 2020 Feb 28;21(5):1645. PMID:32121253 doi:10.3390/ijms21051645
- ↑ Ariazi EA, Jordan VC. Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr Top Med Chem. 2006;6(3):203-15. PMID:16515477
- ↑ Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT. X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J Biol Chem. 2006 Dec 8;281(49):37773-81. Epub 2006 Sep 21. PMID:16990259 doi:http://dx.doi.org/10.1074/jbc.M608410200
