Ferric hydroxamate uptake receptor

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*'''FoxA''' is the ''Pseudomonas'' ferrioxamine receptor <ref>PMID:31385808</ref>.
*'''FoxA''' is the ''Pseudomonas'' ferrioxamine receptor <ref>PMID:31385808</ref>.
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For more details see [[FhuD]].
 
== Disease ==
== Disease ==
''Haemophilus parasuis'' uses Fhu to capture iron and is the cause of the Glasser disease in pigs.
''Haemophilus parasuis'' uses Fhu to capture iron and is the cause of the Glasser disease in pigs.

Current revision

E. coli FhuA complex with ferrichrome and Fe+3 ion (orange) (PDB code 1by5).

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3D structures of Ferric hydroxamate uptake receptor

Updated on 23-June-2024

References

  1. ↑ Forman S, Nagiec MJ, Abney J, Perry RD, Fetherston JD. Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis. Microbiology. 2007 Jul;153(Pt 7):2332-41. PMID:17600077 doi:http://dx.doi.org/10.1099/mic.0.2006/004275-0
  2. ↑ Bonhivers M, Plançon L, Ghazi A, Boulanger P, le Maire M, Lambert O, Rigaud JL, Letellier L. FhuA, an Escherichia coli outer membrane protein with a dual function of transporter and channel which mediates the transport of phage DNA. Biochimie. 1998 May-Jun;80(5-6):363-9. PMID:9782377 doi:10.1016/s0300-9084(00)80004-8
  3. ↑ Rohrbach MR, Braun V, Köster W. Ferrichrome transport in Escherichia coli K-12: altered substrate specificity of mutated periplasmic FhuD and interaction of FhuD with the integral membrane protein FhuB. J Bacteriol. 1995 Dec;177(24):7186-93. PMID:8522527 doi:10.1128/jb.177.24.7186-7193.1995
  4. ↑ Sauer M, Hantke K, Braun V. Ferric-coprogen receptor FhuE of Escherichia coli: processing and sequence common to all TonB-dependent outer membrane receptor proteins. J Bacteriol. 1987 May;169(5):2044-9. PMID:3032906 doi:10.1128/jb.169.5.2044-2049.1987
  5. ↑ Josts I, Veith K, Tidow H. Ternary structure of the outer membrane transporter FoxA with resolved signalling domain provides insights into TonB-mediated siderophore uptake. Elife. 2019 Aug 6;8. pii: 48528. doi: 10.7554/eLife.48528. PMID:31385808 doi:http://dx.doi.org/10.7554/eLife.48528
  6. ↑ Locher KP, Rees B, Koebnik R, Mitschler A, Moulinier L, Rosenbusch JP, Moras D. Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes. Cell. 1998 Dec 11;95(6):771-8. PMID:9865695

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