Fructose-1,6-bisphosphatase

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== Function ==
== Function ==
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'''Fructose-1,6-bisphosphatase''' (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P)<ref>PMID:8382485</ref>. FBP activity in hibernating animals is significantly reduced<ref>PMID:9505421</ref>. '''Fructose-2,6-bisphosphatase''' (F26BP) is the stimulator of phosphofructokinase which is a key enzyme in [[glycolysis]]<ref>PMID:8447185</ref>.
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'''Fructose-1,6-bisphosphatase''' (FBP) is an enzyme in the glucose generating pathway which converts fructose-1,6-bisphosphate to fructose 6-phosphate (F6P)<ref>PMID:8382485</ref>. FBP activity in hibernating animals is significantly reduced<ref>PMID:9505421</ref>.
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*'''Fructose-2,6-bisphosphatase''' (F26BP) is the stimulator of phosphofructokinase which is a key enzyme in [[glycolysis]]<ref>PMID:8447185</ref>.
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*'''Fructose-1,6-bisphosphatase/inoitol monophosphatase''' (FBP/IMP) is a bifunctional enzyme<ref>PMID:11170378</ref>.
== Relevance ==
== Relevance ==

Current revision

Human liver fructose-1,6-bisphosphatase complex with inhibitor (PDB entry 3kc0)

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References

  1. ↑ Zhang Y, Liang JY, Lipscomb WN. Structural similarities between fructose-1,6-bisphosphatase and inositol monophosphatase. Biochem Biophys Res Commun. 1993 Feb 15;190(3):1080-3. PMID:8382485
  2. ↑ Storey KB. Metabolic regulation in mammalian hibernation: enzyme and protein adaptations. Comp Biochem Physiol A Physiol. 1997 Dec;118(4):1115-24. PMID:9505421
  3. ↑ Depre C, Veitch K, Hue L. Role of fructose 2,6-bisphosphate in the control of glycolysis. Stimulation of glycogen synthesis by lactate in the isolated working rat heart. Acta Cardiol. 1993;48(1):147-64. PMID:8447185
  4. ↑ Johnson KA, Chen L, Yang H, Roberts MF, Stec B. Crystal structure and catalytic mechanism of the MJ0109 gene product: a bifunctional enzyme with inositol monophosphatase and fructose 1,6-bisphosphatase activities. Biochemistry. 2001 Jan 23;40(3):618-30. PMID:11170378
  5. ↑ van Poelje PD, Potter SC, Chandramouli VC, Landau BR, Dang Q, Erion MD. Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats. Diabetes. 2006 Jun;55(6):1747-54. PMID:16731838 doi:http://dx.doi.org/10.2337/db05-1443
  6. ↑ van Poelje PD, Potter SC, Erion MD. Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb Exp Pharmacol. 2011;(203):279-301. doi: 10.1007/978-3-642-17214-4_12. PMID:21484576 doi:http://dx.doi.org/10.1007/978-3-642-17214-4_12
  7. ↑ Tsukada T, Takahashi M, Takemoto T, Kanno O, Yamane T, Kawamura S, Nishi T. Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1004-7. Epub 2009 Dec 21. PMID:20045638 doi:10.1016/j.bmcl.2009.12.056

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