Gasdermin
From Proteopedia
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'''Gasdermin''' (GSDM) is the substrate of the inflammatory [[Caspase]] downstream from inflammasomes which activate caspase. Inflammasomes are supramolecular signalling assemblies activating the lytic process against exogenous pathogens. GSDM is required for cytokine release and pyroptosis, a lytic form of programmed cell death) <ref>PMID:31451512</ref>. Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation. GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal. The GSDM family contains 6 members in human. | '''Gasdermin''' (GSDM) is the substrate of the inflammatory [[Caspase]] downstream from inflammasomes which activate caspase. Inflammasomes are supramolecular signalling assemblies activating the lytic process against exogenous pathogens. GSDM is required for cytokine release and pyroptosis, a lytic form of programmed cell death) <ref>PMID:31451512</ref>. Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation. GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal. The GSDM family contains 6 members in human. | ||
| + | *'''Gasdermin B''' has a role in antibacterial defense, inflammatory pathologies and cancer<ref>PMID:37997534</ref>. | ||
*'''Gasdermin D''' is a pore-forming protein involved in cell death of macrophages<ref>PMID:32800355</ref>. | *'''Gasdermin D''' is a pore-forming protein involved in cell death of macrophages<ref>PMID:32800355</ref>. | ||
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References
- ↑ Xia S, Hollingsworth LR 4th, Wu H. Mechanism and Regulation of Gasdermin-Mediated Cell Death. Cold Spring Harb Perspect Biol. 2020 Mar 2;12(3). pii: cshperspect.a036400. doi: , 10.1101/cshperspect.a036400. PMID:31451512 doi:http://dx.doi.org/10.1101/cshperspect.a036400
- ↑ Sarrio D, Colomo S, Moreno-Bueno G. Gasdermin-B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer. FEBS J. 2023 Nov 23. PMID:37997534 doi:10.1111/febs.17018
- ↑ Xia S. Biological mechanisms and therapeutic relevance of the gasdermin family. Mol Aspects Med. 2020 Dec;76:100890. PMID:32800355 doi:10.1016/j.mam.2020.100890
- ↑ Orning P, Lien E, Fitzgerald KA. Gasdermins and their role in immunity and inflammation. J Exp Med. 2019 Nov 4;216(11):2453-2465. doi: 10.1084/jem.20190545. Epub 2019 Sep, 23. PMID:31548300 doi:http://dx.doi.org/10.1084/jem.20190545
- ↑ Liu X, Xia S, Zhang Z, Wu H, Lieberman J. Channelling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov. 2021 May;20(5):384-405. doi: 10.1038/s41573-021-00154-z., Epub 2021 Mar 10. PMID:33692549 doi:http://dx.doi.org/10.1038/s41573-021-00154-z
- ↑ Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. 2018 May;557(7703):62-67. doi: 10.1038/s41586-018-0058-6. Epub 2018 Apr, 25. PMID:29695864 doi:http://dx.doi.org/10.1038/s41586-018-0058-6
