9eo4
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Outward-open structure of human dopamine transporter bound to cocaine== | |
| - | + | <StructureSection load='9eo4' size='340' side='right'caption='[[9eo4]], [[Resolution|resolution]] 2.66Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9eo4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EO4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EO4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.66Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=COC:COCAINE'>COC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9eo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9eo4 OCA], [https://pdbe.org/9eo4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9eo4 RCSB], [https://www.ebi.ac.uk/pdbsum/9eo4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9eo4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SC6A3_HUMAN SC6A3_HUMAN] Infantile dystonia-parkinsonism. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SC6A3_HUMAN SC6A3_HUMAN] Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:11093780, PubMed:1406597, PubMed:15505207, PubMed:19478460, PubMed:8302271). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).[UniProtKB:P23977][UniProtKB:Q61327]<ref>PMID:1406597</ref> <ref>PMID:15505207</ref> <ref>PMID:8302271</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bargmeyer S]] | ||
| + | [[Category: Kalenderoglou IE]] | ||
| + | [[Category: Loland CJ]] | ||
| + | [[Category: Nielsen JC]] | ||
| + | [[Category: Pape T]] | ||
| + | [[Category: Salomon K]] | ||
| + | [[Category: Shahsavar A]] | ||
Current revision
Outward-open structure of human dopamine transporter bound to cocaine
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