7y7i
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7y7i]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y7I FirstGlance]. <br> | <table><tr><td colspan='2'>[[7y7i]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y7I FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y7i OCA], [https://pdbe.org/7y7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y7i RCSB], [https://www.ebi.ac.uk/pdbsum/7y7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y7i ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.42Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y7i OCA], [https://pdbe.org/7y7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y7i RCSB], [https://www.ebi.ac.uk/pdbsum/7y7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y7i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN] [https://www.uniprot.org/uniprot/CENPA_CHICK CENPA_CHICK] Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:14563550). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:15870271).[UniProtKB:P49450]<ref>PMID:14563550</ref> <ref>PMID:15870271</ref> | |
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| + | ==See Also== | ||
| + | *[[Histone 3D structures|Histone 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
chicken KNL2 in complex with the CENP-A nucleosome
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