Interleukin-1 receptor-associated kinase
From Proteopedia
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== Function == | == Function == | ||
'''Interleukin-1 receptor-associated kinase''' (IRAK) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins<ref>PMID:8599092</ref>. | '''Interleukin-1 receptor-associated kinase''' (IRAK) is a kinase involved in signaling innate immune responses from Toll-like receptors and interleukin-1 receptor-related proteins<ref>PMID:8599092</ref>. | ||
| + | *'''Interleukin-1 receptor-associated kinase 1''' (IRAK1) is a key link in the chain of events initiated by the binding of ligands to IL-R and Toll-like receptor <ref>PMID:30279971</ref>. | ||
*'''Interleukin-1 receptor-associated kinase 4''' (IRAK4) has scaffold function in myddosome formation <ref>PMID:30076215</ref>. | *'''Interleukin-1 receptor-associated kinase 4''' (IRAK4) has scaffold function in myddosome formation <ref>PMID:30076215</ref>. | ||
Revision as of 11:07, 7 July 2024
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3D structures of interleukin-1 receptor-associated kinase
Updated on 07-July-2024
References
- ↑ Cao Z, Henzel WJ, Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science. 1996 Feb 23;271(5252):1128-31. PMID:8599092
- ↑ Singer JW, Fleischman A, Al-Fayoumi S, Mascarenhas JO, Yu Q, Agarwal A. Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy. Oncotarget. 2018 Sep 7;9(70):33416-33439. PMID:30279971 doi:10.18632/oncotarget.26058
- ↑ De Nardo D, Balka KR, Cardona Gloria Y, Rao VR, Latz E, Masters SL. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling. J Biol Chem. 2018 Sep 28;293(39):15195-15207. PMID:30076215 doi:10.1074/jbc.RA118.003314
